Basiliximab (Simulect)
Abbreviated
medical protocols from EdREN, the
website of the Renal Unit of the Royal Infirmary of Edinburgh
Important: Protocol superseded July 2009 - see new version here at www.edren.co.uk.
That website is in development - you can ignore the 'This website is not ready' signs ONLY for the Transplant protocols. Others are not updated or fully transferred.
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Indication
- High risk patients receiving kidney transplants *
- All patients receiving pancreas or kidney/pancreas transplants
- Patients expected to have Delayed Graft Function e.g. NHBD grafts.
Dose
The first dose must not be administered unless it is absolutely certain that the patient will receive the graft.
Reconstitution
1. 5ml water for injection (provided) should be added to the vial containing the Basiliximab powder.
2. Shake the vial gently to dissolve the powder
3. The solution should be used immediately. (It can be stored for 24 hours in the fridge or 4 hours at room temperature.)
Administration
There are two possible routes of administration
1. Intravenous bolus injection or
2. Intravenous infusion over 20-30 minutes. (Final volume of at least 50ml using sodium chloride 0.9% or dextrose 5%.)
Compatibility
Basiliximab should not be mixed with other medicines/substances and should always be given through a separate infusion line.
Adverse Effects
Severe acute
hypersensitivity reactions have been observed both on initial exposure
and re-exposure to basiliximab. These include anaphylactoid-type
reactions. If severe hypersensitivity reaction occurs, therapy
with basiliximab must be permanently discontinued and no further dose
administered.
Side Effects
Basiliximab does
not appear to add to the background of side effects seen in organ
transplantation patients as a consequence of their underlying disease
and concurrent administration of immunosuppressants.
Transplant protocols developed on the Edinburgh Transplant Unit. This page first published March 2002 by Amit Adlakha, updated November 2006 and last modified Tuesday, August 11, 2009.
NOTE
that the accuracy of any statements in this information CANNOT
be guaranteed. It is published in the belief that it is correct,
and we endeavour to keep it so - but we do make mistakes. Furthermore,
over some subjects there are differing opinions, or differing
degrees of certainty. We have usually not attempted to discuss
these here because the aim has been to provide an immediate and
brief guide. In all areas, prior medical knowledge is assumed.
The EdRenHANDBOOK is not suitable for use by those without such
a background. Contact us by email
or at the address given at the foot of the contents
page
with any comments or corrections.
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